Orlistat, the active ingredient in Xenical, works as a lipase inhibitor that aids weight loss as well as weight management. The role of lipase, an enzyme in your body, is to break down fat. But orlistat blocks the lipases, and prevents 30% of your dietary fat from being absorbed. Xenical works by forming a bond with the lipase enzymes so that they are easily prevented from breaking down fat from triglycerides into free fatty acids, a form of fat which can be absorbed by your body. This means that your body receives fewer calories, helping you to lose weight.
Xenical is the most effective weight loss medication to date, and provides a three-pronged approach to weight loss. It also helps weight maintenance and prevents weight regain. This weight loss helps with other weight-related health problems such as type 2 diabetes, high cholesterol and high blood pressure.
Orlistat has been assessed in clinical trials which included more than 7100 patients. It was found that people treated with Xenical, who were taking a reduced-calorie diet containing no more than 30% of calories from fat, achieved better weight loss when compared to people who lost weight through diet alone.
The studies were designed so that all participants ate a reduced-calorie diet for 4 weeks, followed by diet and orlistat for 52 weeks. After this period, patients on a combination of diet and orlistat lost an average of 2 times more weight when compared to those who lost weight through diet alone. In addition, 69.1% of patients on Xenical lost an average of 13 lbs after 3 months and 19 lbs after 1 year.
When Xenical is combined with a healthy diet and exercise, it's known to improve many weight-related health risks. Weight loss with orlistat can:
What happens if I miss a dose or overdose?
Missing a dose of Xenical simply means that the fat in your next meal will be digested, and therefore, your body will absorb all the calories from that particular meal. But once you resume your orlistat dosage, the benefits return promptly and all you need to do is take a dose of Xenical with your next meal. Clinical trials have revealed that taking additional doses of this weight loss pill in no way improved or accelerated weight loss. On the contrary, if you take more Xenical than required, your chances of enhanced side effects became higher.
Interaction with other medicines
Xenical, like most prescription medication may interact with other drugs. It's essential that you discuss all the medications that you are currently taking with your doctor. Your list of current medications should include all prescription, over-the-counter and herbal medications.
Can pregnancy and breastfeeding women take Xenical?
Xenical has not undergone adequate, well-controlled trials in pregnant and lactating women; it is therefore not known if this weight loss drug is excreted in breast milk. As a safety precaution it has been recommended that pregnant and nursing women should refrain from using Xenical.